Name: LAHERU, Dhruvkumar

Candidate number:? (laheru d)

Theme: Liver Function

 

OPTION LIST

 

A	alpha1 – Antitrypsin deficiency	I	Viral hepatitis
B	Alcoholic liver injury	J	Cirrhosis
C	Iron overload	K	Acute liver injury
D	Primary biliary cirrhosis	L	Chronic liver injury
E	Primary sclerosing cholangitis	M	Benign liver cyst
F	Autoimmune hepatitis	N	Secondary hepatic tumour
G	Acute biliary obstruction	O	Haemangioma
H	Wilson’s disease	P	Leiomyosarcoma

 

 

Match the pathological features stated below with the most likely diagnosis from the list above.

 

For each scenario, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. A gentleman with severe progressive neurological disability. A Kayser-Fleischer corneal limbus is noted on examination. Serum has ↓ caeruloplasmin.

 

2. General malaise and jaundice in a patient known to be a drug-abuser. Histological features of note include: apoptotic bodies, portal tract inflammation and cholestasis.

 

 

3. A middle-aged man complaining of tiredness, arthralgia and slate-grey skin pigmentation. Tests reveal an abnormal LFT. Joint X-rays show chondrocalcinosis. A Perl’s stain is performed following liver biopsy.

 

 

4. An emphysematic woman has a liver biopsy that reveals Periodic acid Schiff positive and distase-resistant globules.

 

 

5. A lady with ulcerative colitis has recently been suffering from fluctuating symptoms of jaundice, pruritis, abdominal pain and fatigue. Tests reveal elevated Alk phos, elevated bilirubin and hypergammaglobulinaemia. An ERCP performed later showed a structure with a “beaded” appearance.

 

 

 

ANSWERS

1. H

2. I

3. C

4. A

5. E